Search results for "Cytotoxic T-lymphocyte precursor frequency"

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T-cell hyperreactivity of NZB mice against H-2 identical cells

1983

NZB mice serve as a model for human systemic lupus erythematodes. T-cell abnormalities in this strain have previously been described. In this paper the cytotoxic T lymphocyte precursor (CTL-p) frequencies of NZB mice against H-2 allogeneic and H-2 syngeneic cells are investigated and compared with those of the normal strain BALB/c. The CTL-p frequency in NZB lymphocytes against H-2 allogeneic cells equals that in normal mouse strains (i.e. 1/7500). The NZB anti BALB/c response is in the same order of magnitude. No corresponding BALB/c anti NZB response was elicited. The results suggest abnormally high sensitivity of NZB CTL-p to helper signals.

T cellImmunologychemical and pharmacologic phenomenaurologic and male genital diseasesMiceRheumatologyimmune system diseasesAnimalsLupus Erythematosus SystemicImmunology and AllergyCytotoxic T cellMedicineskin and connective tissue diseasesMice Inbred BALB CMice Inbred NZBStrain (chemistry)business.industrySystemic lupusT-Lymphocytes Helper-InducerDisease Models AnimalCTL*medicine.anatomical_structureCytotoxic T-lymphocyte precursor frequencyImmunologybusinessT-Lymphocytes CytotoxicRheumatology International
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